Decreased pancreatic acinar cell number in type 1 diabetes

Pancreatic Acinar Cell Carcinoma

Pancreatic acinar cell carcinoma (ACC) is a rare malignant neoplasm that accounts for 1-2% of all pancreatic neoplasms. Here we report two cases of ACC and describe their clinical features, the therapies used to treat them, and their prognosis. The first patient was a 65-year-old woman who had an abdominal CT scan for a urinary infection. Fortuitously, a rounded and well-delimited corporeal pan...

Generation of insulin-secreting cells from pancreatic acinar cells of animal models of type 1 diabetes.

We recently found that pancreatic acinar cells isolated from normal adult mouse can transdifferentiate into insulin-secreting cells in vitro. Using two different animal models of type 1 diabetes, we show here that insulin-secreting cells can also be generated from pancreatic acinar cells of rodents in the diabetic state with absolute insulin deficiency. When pancreatic acinar cells of streptozo...

Discussion: Pancreatic Acinar Cell Pathophysiology

The high level of interest in the pancreatic acinar cell over the past 25 years is a reflection of the fact that this system is a paradigm for the study of protein synthesis, sorting, and secretion. Moreover, pancreatic inflammation is a serious clinical problem that may relate to a disorder in the basic organization of this cell. The discussions by Pandol, Steer, Grendell, and myself are close...

Understanding Pancreatic Secretion in Type 1 Diabetes

Regulated Exocytosis in the Pancreatic Acinar Cell

The studies reported here will summarize the major events taking place during the synthesis, intracellular transport and discharge of secretory proteins from the pancreatic acinar cell. We will summarize the work that led to the definition of the regulated secretory pathway in the acinar cell followed by an update of the major steps in the pathway to incorporate new information on vesicular tra...